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Recombinant Equine Metalloproteinase Inhibitor 2 (TIMP2)
Product Overview
BioVenic's Recombinant Equine Metalloproteinase Inhibitor 2 (TIMP2) is a recombinant protein expressed from E.coli. Its predicted molecular weight is 11.1 kDa. The purity is>95% (SDS-PAGE).
Specifications
Target Information
Equine metalloproteinase inhibitor 2 (TIMP-2) is a regulatory protein that plays a dual role in the extracellular matrix (ECM) by inhibiting matrix metalloproteinases (MMPs) and facilitating the activation of pro-MMP-2. TIMP-2 is particularly effective at binding to MMP-2, which is crucial for tissue remodeling and maintaining the structural integrity of tissues like the kidney. It is upregulated by cytokines and growth factors and is linked to fibrosis and kidney disease pathways. TIMP-2 is also a prognostic biomarker in acute kidney injury, indicating its importance in clinical diagnostics.
Shipping and Storage
This product is shipped with dry ice. It is recommended to aliquote as needed and store at -80°C upon receipt. Reconstituted protein solution can be stored at 4°C for 1 week, at < -80°C for 12 months.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Reconstitute in 10mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL.Aliquote the reconstituted solution to minimise freeze-thaw cycles.