Recombinant Mouse Carbonic Anhydrase 4 (Ca4), C-His

Mouse Carbonic Anhydrase 4 (Ca4) is a zinc-containing metalloenzyme that catalyzes the reversible hydration of carbon dioxide to bicarbonate and protons. It is expressed in various tissues, including the eye, kidney, and epithelial cells. In the eye, Ca4 plays a crucial role in maintaining the pH and fluid balance of the aqueous humor, and its dysfunction has been implicated in ocular diseases such as glaucoma. In the kidney, Ca4 contributes to acid-base homeostasis by regulating bicarbonate reabsorption in the proximal tubule. Additionally, Ca4 has been found to be overexpressed in certain types of cancer, where it may facilitate tumor growth and metastasis by modulating the tumor microenvironment's pH. Research on Ca4's function and regulation could provide insights into potential therapeutic targets for related diseases.