Mouse Anti-Canine ADP Ribosylation Factor Like GTPase 13B (ARL13B) Monoclonal Antibody

Canine ADP ribosylation factor like GTPase 13B (ARL13B) is a member of the ADP-ribosylation factor-like (ARL) family of small GTPases, which are pivotal in regulating cellular processes such as intracellular trafficking, vesicle formation, and ciliary function. ARL13B, specifically, plays a crucial role in the maintenance and regulation of primary cilia, hair-like cellular projections that are essential for various signaling pathways and cellular sensing mechanisms. As a molecular target, ARL13B is significant for its potential implications in understanding and treating ciliopathies, a group of disorders associated with dysfunction of cilia. Given its role in ciliary biology, ARL13B is also relevant to research on conditions such as polycystic kidney disease, retinal degeneration, and certain types of cancer that involve ciliary abnormalities.