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Mouse Anti-Canine Tumor Protein p53 Monoclonal Antibody

Cat. No.VD8N105

Product TypeAnimal-targeted Antibodies

Size

Product Overview

BioVenic mouse monoclonal antibody is specific for canine tumor protein p53. It can be applied to WB assay of canine tumor protein p53.

Specifications

Application WB
Clonality Monoclonal
Classification Primary Antibody
Clone G3N69
Host Mouse
Target Species Canine
Species Reactivity Canine
Specificity Canine Tumor Protein p53
Isotype IgG
Immunogen Purified recombinant canine p53 (C-terminus) protein fragments
Concentration 1 mg/mL
Conjugation Unconjugated
Physical State Liquid

Target Information

p53, also known as tumor protein p53 or TP53, is a multifunctional protein that plays a central role in the regulation of the cell cycle and apoptosis. It is often referred to as the "guardian of the genome" due to its crucial function in preventing cancer formation. p53 is activated in response to DNA damage, hypoxia, and other cellular stresses, and it mediates cell cycle arrest, allowing time for DNA repair or triggering apoptosis if the damage is irreparable. The protein is involved in a wide range of cellular processes, including senescence, DNA repair, and the maintenance of genomic stability. It achieves these functions by acting as a transcription factor that regulates the expression of numerous target genes involved in cell cycle control, apoptosis, and DNA repair.

Target Canine Tumor Protein p53
Target Synonym TP53; P53
Gene ID 403869
UniProt ID Q29537

Shipping and Storage

This product is shipped with ice gel packs. Store at -20°C (up to 12 months) on receipt. Avoid repeated freezing and thawing as this may denature the antibody.

Documents

COA

To request a Certificate of Analysis, please enter the Lot No. in the search box. Note: Certificate of Analysis not available for kits.

The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.

References

  1. Oren, Moshe. "Regulation of the p53 tumor suppressor protein." Journal of Biological Chemistry 274.51 (1999): 36031-36034.
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