Mouse Anti-Chicken G Protein O Polypeptide (GNAO1) Monoclonal Antibody

Chicken G protein O polypeptide (GNAO1) is a pivotal component of the G protein-coupled receptor (GPCR) signaling pathway, playing a significant role in various physiological processes, particularly in the nervous system. GNAO1, encoding the Gαo subunit, is crucial for neural circuit formation and has been implicated in the pathogenesis of neurodevelopmental disorders such as developmental and epileptic encephalopathy (DEE). This protein is highly expressed in the central nervous system, where it influences neural differentiation and cytoskeletal remodeling, essential for the growth and guidance of neurites. In chickens, GNAO1 may serve as a key factor in neurodevelopment and could be involved in the resilience to stress-induced memory deficits. The protein's regulation of Rho GTPase signaling pathways, which are crucial for cytoskeletal remodeling and neuronal connectivity, positions GNAO1 as a potential therapeutic target for neurodegenerative diseases and conditions where neuronal connectivity is compromised.