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Recombinant Canine Interleukin-10 (IL10)
Product Overview
BioVenic's Recombinant Canine Interleukin-10 (IL10) is a recombinant protein expressed from E.coli. Its predicted molecular weight is 18.9 kDa. The purity is>97% (SDS-PAGE).
Specifications
Target Information
Canine IL-10 protein is a pleiotropic cytokine that can exert both immunostimulatory and immunosuppressive effects on various cell types. It is a potent immunosuppressant of macrophage functions, inhibiting the accessory function and antigen-presenting capacity of monocytes by downregulating class II MHC expression. IL-10 can inhibit monocyte/macrophage-dependent, antigen-stimulated cytokine synthesis, especially IFN-gamma, and also limits the production of pro-inflammatory cytokines. As an immunostimulatory cytokine, IL-10 enhances B cell viability, proliferation, Ig secretion, and class II MHC expression. It also acts as a growth co-stimulator for thymocytes and mast cells, and enhances cytotoxic T cell development.
Shipping and Storage
This product is shipped with dry ice. It is recommended to aliquote as needed and store at -80°C upon receipt. Reconstituted protein solution can be stored at 4°C for 1 week, at < -80°C for 12 months.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.Aliquote the reconstituted solution to minimise freeze-thaw cycles.