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Recombinant Clostridioides difficile Toxin B (tcdB), N-His-SUMO

Name: Recombinant Clostridioides difficile Toxin B (tcdB), N-His-SUMO
SKU: VG9C222
Rating: 5 (1 reviews)

Cat. No.VG9C222

Product TypeVeterinary Antigens

Size

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Product Overview

BioVenic's Recombinant Clostridioides difficile Toxin B (tcdB), N-His-SUMO is a recombinant protein expressed from E.coli. Its predicted molecular weight is 43.1 kDa. The purity is>90% (SDS-PAGE).

Specifications

Type Recombinant Protein

Species Bacterium

Expression System E.coli

Purity >90% (SDS-PAGE)

Predicted Molecular Weight 43.1 kDa

Physical State Lyophilized

Formulation The buffer before lyophilization is a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.

Target Information

In the veterinary field, Clostridioides difficile Toxin B (tcdB) is a significant virulence factor causing diseases associated with C. difficile, including diarrhea and pseudomembranous colitis in animals. TcdB glucosylates small GTPase proteins using its N-terminal glucosyltransferase domain (GTD), leading to actin depolymerization and cell death. This toxin is required for the high virulence of pathogenic strains in animal models and is sufficient to induce a range of diseases in humans.

Protein Clostridioides difficile Toxin B (tcdB)

Protein Synonym Toxin B; Glucosyltransferase TcdB; tcdB; toxB;Clostridium difficile Toxin

UniProt ID P18177

Shipping and Storage

This product is shipped with dry ice. Avoid repeated freezing and thawing. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use.

Documents

Datasheet

COA

To request a Certificate of Analysis, please enter the Lot No. in the search box. Note: Certificate of Analysis not available for kits.

The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.

User Note

Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Reconstitute to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.Aliquote the reconstituted solution to minimise freeze-thaw cycles.