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Recombinant Feline Thiopurine S-Methyltransferase (TPMT)
Product Overview
BioVenic's Recombinant Feline Thiopurine S-Methyltransferase (TPMT) is a recombinant protein expressed from E.coli. Its predicted molecular weight is 28.3 kDa. The purity is>85% (SDS-PAGE).
Specifications
Target Information
In felines, thiopurine S-methyltransferase (TPMT) is a cytosolic enzyme that metabolizes thiopurine drugs such as 6-mercaptopurine (6-MP) and azathioprine (AZA) by catalyzing their S-methylation into inactive metabolites. TPMT activity is influenced by genetic polymorphisms, leading to individual variations in drug tolerance. Genetic testing of TPMT can predict an individual's ability to metabolize thiopurine drugs, optimizing dosing and reducing adverse effects.
Shipping and Storage
This product is shipped with ice packs. Lyophilized protein can be stored at -20°C for 1 year. After reconstitution, the protein solution can be stored at 2-8°C for 2-7 days.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Aliquot the reconstituted solution to minimize freeze-thaw cycles.