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Recombinant Influenza A H5N8 Hemagglutinin HA1 subunit (HA1), C-His
Product Overview
BioVenic's Recombinant Influenza A H5N8 Hemagglutinin HA1 subunit (HA1), C-His is a recombinant protein expressed from Baculovirus-insect cell. Its predicted molecular weight is 38.7 kDa. The purity is>95% (SDS-PAGE). The endotoxin level is <1 EU/μg (LAL).
Specifications
Target Information
H5N8 is a subtype of the influenza A virus that is highly lethal to wild birds and poultry. It is generally not associated with human infections. The hemagglutinin (HA) protein serves as the primary target for the host's immune system. For the avian influenza virus to be infectious, the HA precursor (HA0) must be cleaved into HA1 and HA2 subunits. The HA1 subunit contains subtype-specific neutralizing epitopes, while the HA2 subunit has broad neutralizing epitopes. These characteristics make HA1 and HA2 promising candidates for developing both subtype-specific and universal influenza vaccines.
Shipping and Storage
This product is shipped with dry ice. Avoid repeated freezing and thawing. Store for 4 weeks at 2-8°C, for 12 months at -20°C or -80°C.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Aliquote the reconstituted solution to minimise freeze-thaw cycles.
References
- Shirvani, Edris et al. "Contributions of HA1 and HA2 Subunits of Highly Pathogenic Avian Influenza Virus in Induction of Neutralizing Antibodies and Protection in Chickens." Frontiers in microbiology vol. 11 1085. 5 Jun. 2020