Recombinant Mouse Alpha-1-Antitrypsin 1-5 (Serpina1e), C-His

Mouse Alpha-1-Antitrypsin 1-5 (Serpina1e) is a member of the serine protease inhibitor (serpin) superfamily, which functions as a protease inhibitor to regulate proteolytic cascades. Serpina1e is primarily expressed in the liver and secreted into the bloodstream, where it inhibits the activity of proteases such as neutrophil elastase and proteinase 3. In mice, Serpina1e plays a protective role in preventing excessive proteolysis that can lead to tissue damage and inflammation. It has been implicated in various pathological conditions, including pulmonary emphysema, chronic obstructive pulmonary disease, and certain inflammatory disorders. Research on Serpina1e in mice has contributed to our understanding of its role in maintaining protease-antiprotease balance and its potential as a therapeutic target for diseases associated with protease-mediated tissue destruction.