Recombinant Mouse Pyrethroid Hydrolase Ces2e (Ces2e), C-His

Mouse Pyrethroid Hydrolase Ces2e (Ces2e) is a member of the carboxylesterase family of enzymes. It is involved in the metabolism of various compounds, including drugs and toxins. Ces2e is expressed primarily in the liver and plays a role in the detoxification and biotransformation of xenobiotics. It catalyzes the hydrolysis of carboxylester bonds, facilitating the elimination of harmful substances from the body. In the context of pyrethroid insecticides, Ces2e can hydrolyze these compounds, potentially reducing their toxicity in mammals. Research suggests that Ces2e may influence lipid metabolism and the absorption of dietary fats. Its expression is regulated by various factors, including dietary components and hormonal signals. Studies have shown that Ces2e-deficient mice exhibit altered drug metabolism and lipid profiles, highlighting its importance in maintaining metabolic homeostasis. Understanding the functions and regulation of Ces2e could contribute to the development of strategies for modulating drug metabolism and treating metabolic disorders.