Recombinant Rabies Virus Phosphoprotein (P), N-His

Rabies virus phosphoprotein (P) is a multifunctional protein that serves as an essential component in the viral replication machinery of rabies virus. It acts as a cofactor for the viral polymerase, binding to the complex of viral genomic RNA and the nucleoprotein (N protein), which is crucial for replication. Additionally, it plays a significant role in immune evasion by binding to STAT transcription factors, thereby inhibiting the host's innate immune response
.In the context of veterinary medicine, understanding the function of the P protein is vital for developing strategies to combat rabies, a disease that poses a significant threat to both animals and humans. The P protein's role in viral replication and its ability to antagonize the host's interferon response make it a key target for antiviral therapies and vaccine development.