Recombinant Swine Alpha-Synuclein (SNCA), N-His

Swine Alpha-synuclein (SNCA) is a protein that plays a pivotal role in synaptic activity within Swine species. It is crucial for the modulation of synaptic vesicle trafficking and the subsequent release of neurotransmitters1. As a monomer, it aids in synaptic vesicle exocytosis by promoting vesicle priming, fusion, and the expansion of exocytotic fusion pores. This protein also increases local Ca(2+) release from microdomains, which is essential for enhancing ATP-induced exocytosis2. Furthermore, it serves as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components known as SNAREs (Soluble NSF Attachment Protein REceptors)3. This chaperone activity is vital for maintaining normal SNARE complex assembly, particularly during aging. Additionally, Swine Alpha-synuclein is involved in the regulation of dopamine neurotransmission by interacting with the dopamine transporter (DAT1), thereby modulating its activity4.