Mouse Anti-Bovine Akt1 Monoclonal Antibody

Akt1, a central player in the phosphoinositide 3-kinase (PI3K) signaling pathway, is involved in a multitude of cellular processes, including glucose metabolism, protein synthesis, cell cycle progression, apoptosis inhibition, and cell growth. Akt1 is activated by phosphorylation in response to various stimuli, such as growth factors, cytokines, and insulin, which leads to its translocation to the plasma membrane and subsequent activation of downstream targets. This protein kinase is a key regulator of the mammalian target of rapamycin (mTOR) signaling pathway, which is essential for cell growth and proliferation. Akt1's role in promoting cell survival and inhibiting apoptosis makes it a significant factor in many diseases, particularly cancer, where its overactivation can lead to uncontrolled cell growth and resistance to cell death.