Mouse Anti-Canine SERCA2 ATPase Monoclonal Antibody

Canine SERCA2 ATPase, or sarcoplasmic/endoplasmic reticulum Ca2+ ATPase, is a key calcium pump that plays a central role in calcium cycling and signaling within canine cardiovascular tissues. This enzyme is responsible for the reuptake of cytosolic Ca2+ into the sarcoplasmic reticulum (SR), which is crucial for muscle relaxation and the excitation-contraction coupling process in cardiomyocytes. SERCA2 is the dominant isoform in both cardiac and vascular myocytes, highlighting its importance in canine cardiac function. Abnormalities in SERCA2 function have been implicated in heart diseases, and its activity can be modulated by post-translational modifications such as phosphorylation. Understanding the role of canine SERCA2 ATPase is vital for insights into calcium homeostasis, cardiac muscle physiology, and the development of therapeutic strategies for heart diseases in dogs.