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Mouse Anti-Porcine Aconitase 2 Mitochondrial (ACO2) Monoclonal Antibody
Product Overview
BioVenic mouse monoclonal antibody is specific for aconitase 2 mitochondrial. It is affinity purified by protein G. It can be applied to WB, IHC and ELISA assays of aconitase 2 mitochondrial.
Specifications
Target Information
Porcine aconitase 2 mitochondrial (pACO2), also known as iron regulatory protein 1 (IRP1), is a crucial enzyme involved in the tricarboxylic acid (TCA) cycle, also referred to as the citric acid cycle or Krebs cycle, within the mitochondria of pig cells. pACO2 is responsible for the isomerization of citrate to isocitrate, a key step in the cycle that generates energy in the form of ATP. This protein also plays a vital role in iron homeostasis as a part of the iron regulatory system. It functions as an iron-sulfur (Fe-S) cluster assembly enzyme under iron-replete conditions and switches to an RNA-binding protein under iron-deficient conditions, thereby regulating the expression of iron-related genes.
Shipping and Storage
This product is shipped with ice gel packs. Store at -20°C (up to 12 months) on receipt.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
References
- Kim, Seok-Jo, et al. "Mitochondria-targeted Ogg1 and aconitase-2 prevent oxidant-induced mitochondrial DNA damage in alveolar epithelial cells." Journal of Biological Chemistry 289.9 (2014): 6165-6176.