Mouse Anti-Porcine Interleukin-12 Subunit Beta (IL12B) Monoclonal Antibody

Porcine interleukin-12 subunit beta (IL-12β), also known as the p40 subunit, is a vital component of the IL-12 cytokine, which is a heterodimeric protein consisting of two subunits, p35 and p40. This subunit is encoded by the IL12B gene and plays a significant role in the immune response, particularly in the initiation of Th1 cell-mediated immunity.IL-12β is secreted by antigen-presenting cells such as dendritic cells and macrophages in response to pathogens. It binds to the IL-12 receptor (IL-12R) on T cells and natural killer (NK) cells, leading to the activation of signal transducer and activator of transcription 4 (STAT4) and the production of interferon-gamma (IFN-γ). This signaling cascade is essential for the development of Th1 cells and the subsequent pro-inflammatory immune response.