Rabbit Anti-Myosin Phosphatase Targeting Subunit 1 (MYPT1) Polyclonal Antibody

Myosin phosphatase targeting subunit 1 (MYPT1), also known as the regulatory subunit of myosin light chain phosphatase (MLCP), is integral to the regulation of smooth muscle contraction and cell motility. MYPT1 binds to the catalytic subunit of MLCP, influencing its activity and thereby controlling the phosphorylation state of myosin light chains. This phosphatase activity is critical for counterbalancing kinase-mediated myosin phosphorylation, which is essential for muscle contraction. Dysregulation of MYPT1 and the MLCP complex can lead to various pathophysiological conditions, including cardiovascular diseases and disorders of cell migration and proliferation. Targeting MYPT1 presents a potential therapeutic strategy for modulating smooth muscle tone and treating related conditions. Understanding the molecular mechanisms involving MYPT1 is vital for developing targeted interventions in these disease contexts.