Mouse Anti-Canine Alpha 1 Antitrypsin Monoclonal Antibody

Canine alpha 1 antitrypsin (AAT) is a serine protease inhibitor that plays a crucial role in protecting tissues from enzymes of inflammatory cells, particularly neutrophil elastase. It is primarily produced in the liver and circulates in the bloodstream, where it helps maintain the balance of proteases and antiproteases. Deficiency in AAT can lead to various health issues, including chronic obstructive pulmonary disease (COPD) and liver diseases due to the accumulation of abnormally folded AAT proteins in hepatocytes. In dogs, genetic polymorphisms of AAT have been identified, indicating potential variations in serum levels and responses to inflammation. Understanding AAT's function in dogs is essential for insights into its role in immune regulation and potential therapeutic applications in managing related diseases.