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Mouse Anti-Porcine Protein Phosphatase 2A Catalytic (PP2A-C) Alpha Monoclonal Antibody
Product Overview
BioVenic mouse monoclonal antibody is specific for porcine protein phosphatase 2A catalytic alpha. It can be applied to WB, IF and ICC assays of porcine protein phosphatase 2A catalytic alpha.
Specifications
Target Information
Protein phosphatase 2A catalytic alpha (PP2A-Cα) is a subunit of the PP2A complex, which is a highly conserved serine/threonine phosphatase involved in a multitude of cellular processes. PP2A is composed of a scaffold A subunit, a catalytic C subunit, and a regulatory B subunit, with the Cα subunit being one of the isoforms of the catalytic subunit. PP2A-Cα plays a critical role in reversing the effects of protein kinases by removing phosphate groups from serine and threonine residues on target proteins. This activity is essential for the regulation of cell growth, division, and the maintenance of cellular homeostasis. The PP2A complex is also implicated in the control of signal transduction pathways, including those involved in apoptosis and the response to DNA damage.
Shipping and Storage
This product is shipped with ice gel packs. Store at -20°C (up to 12 months) on receipt. Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
References
- Gergs, Ulrich, et al. "Overexpression of the catalytic subunit of protein phosphatase 2A impairs cardiac function." Journal of Biological Chemistry 279.39 (2004): 40827-40834.