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Rabbit Anti-Fragile X Mental Retardation Protein (FMRP) Polyclonal Antibody

Cat. No.VD7N388

Product TypeAnimal-targeted Antibodies

Size

Product Overview

BioVenic rabbit polyclonal antibody is specific for fragile X mental retardation protein. It can be applied to IHC and WB of fragile X mental retardation protein.

Specifications

Application IHC; WB
Clonality Polyclonal
Classification Primary Antibody
Clone L13N61
Host Rabbit
Target Species Chicken
Species Reactivity Chicken
Specificity Fragile X Mental Retardation Protein
Isotype IgG
Immunogen Synthetic phospho peptide
Purification Antigen Affinity Purified
Purity > 90%
Conjugation Unconjugated
Buffer 10 mM HEPES with 150 mM NaCl, 100 µg per ml BSA and 50% glycerol,µ
Physical State Liquid

Target Information

The fragile X mental retardation protein (FMRP) is a critical regulatory protein involved in the development and function of the nervous system. FMRP plays a significant role in the control of protein synthesis, particularly in the regulation of the translation of specific messenger RNAs (mRNAs) in neurons. The absence or dysfunction of FMRP is associated with Fragile X Syndrome (FXS), the leading inherited cause of intellectual disability and autism spectrum disorders. FMRP is considered a target for therapeutic intervention in FXS due to its pivotal role in neuronal development and synaptic plasticity. Targeting FMRP involves strategies aimed at restoring its normal function or compensating for its loss.

Target Fragile X Mental Retardation Protein
Target Synonym FMR1
Taxonomy ID 35357
Gene ID 24948
UniProt ID Q80WE1

Shipping and Storage

This product is shipped with ice gel packs. Store at -20°C (up to 12 months) on receipt. Avoid repeated freezing and thawing as this may denature the antibody.

Documents

COA

To request a Certificate of Analysis, please enter the Lot No. in the search box. Note: Certificate of Analysis not available for kits.

The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.

References

  1. Smidak, Roman, et al. "Reduced levels of the synaptic functional regulator FMRP in dentate gyrus of the aging sprague-dawley rat." Frontiers in aging neuroscience 9 (2017): 384.
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