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Recombinant Bovine Complement Factor H (CFH)
Product Overview
BioVenic's Recombinant Bovine Complement Factor H (CFH) is a recombinant protein expressed from E.coli. Its predicted molecular weight is 44.4 kDa. The purity is>95% (SDS-PAGE).
Specifications
Target Information
Bovine complement Factor H (CFH) in Bovines is a crucial regulatory protein of the complement system, which is a part of the innate immune system. CFH plays a vital role in modulating the alternative pathway of complement activation by controlling the conversion of C3 to C3b, thus preventing excessive inflammation and tissue damage. It is also involved in the binding of immune complexes and the clearance of apoptotic cells. The application of CFH includes research in immunology and the development of therapeutic strategies for diseases associated with dysregulated complement activation, such as atypical hemolytic-uremic syndrome and macular degeneration.
Shipping and Storage
This product is shipped with dry ice. It is recommended to aliquot as needed and store at -80°C upon receipt. Reconstituted protein solution can be stored at 4°C for 1 week, at < -80°C for 12 months. Avoid repeated freezing and thawing.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Reconstitute in 10mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Aliquot the reconstituted solution to minimise freeze-thaw cycles.
References
- Soames, C J. et al. Prediction from sequence comparisons of residues of factor H involved in the interaction with complement component C3b.The Biochemical journal. 1996, 315 ( Pt 2): 523-31.