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Recombinant Bovine Interstitial Collagenase (MMP1), N-His
Product Overview
BioVenic's Recombinant Bovine Interstitial Collagenase (MMP1), N-His is a recombinant protein expressed from E.coli. Its predicted molecular weight is 55.1 kDa. The purity is>90% (SDS-PAGE).
Specifications
Target Information
Bovine interstitial collagenase (MMP1) is an enzyme found in cattle that is responsible for the breakdown of the extracellular matrix, specifically targeting fibrillar collagens such as types I, II, and III. This protein is crucial in physiological processes like tissue remodeling and wound healing, where it cleaves collagen within the helical domain. It's also involved in pathological conditions such as arthritis and tumor invasion. In the medical field, understanding and utilizing Bovine interstitial collagenase can aid in the development of treatments for diseases associated with abnormal collagen metabolism.
Shipping and Storage
This product is shipped with dry ice. It is recommended to aliquot as needed and store at -80°C upon receipt. Reconstituted protein solution can be stored at 4°C for 1 week, at < -80°C for 12 months. Avoid repeated freezing and thawing.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Reconstitute in 10mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Aliquot the reconstituted solution to minimise freeze-thaw cycles.
References
- Daraban Bocaneti, Florentina. et al. Expression of collagenases (matrix metalloproteinase-1, -8, -13) and tissue inhibitor of metalloproteinase-3 (TIMP-3) in naturally occurring Sheep cutaneous fibropapillomas.Frontiers in veterinary science. 2023,.9 1072672: 12