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Recombinant Bovine Urokinase-Type Plasminogen Activator (PLAU), N-His
Product Overview
BioVenic's Recombinant Bovine Urokinase-Type Plasminogen Activator (PLAU), N-His is a recombinant protein expressed from E.coli. Its predicted molecular weight is 21.7 kDa. The purity is>90% (SDS-PAGE).
Specifications
Target Information
Bovine plasminogen activator, urokinase (uPA) is a serine protease that plays a pivotal role in extracellular matrix remodeling in Bovines. It is instrumental in processes such as cell migration, tissue repair, and embryonic development by catalyzing the conversion of plasminogen to plasmin. The activity of uPA is tightly regulated through interactions with its receptor, uPAR, which is anchored to the cell membrane and localizes uPA activity to the cell surface. This interaction is crucial for mediating cellular events like fertilization and early embryonic development in cattle. The uPA system, including its inhibitor PAI-1, is also implicated in the regulation of oocyte maturation, suggesting its importance in reproductive biology.
Shipping and Storage
This product is shipped with dry ice. It is recommended to aliquot as needed and store at -80°C upon receipt. Reconstituted protein solution can be stored at 4°C for 1 week, at < -80°C for 12 months. Avoid repeated freezing and thawing.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Reconstitute in 10mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Aliquot the reconstituted solution to minimise freeze-thaw cycles.