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Recombinant Langya Virus Fusion Protein (F), N-His
Product Overview
BioVenic's Recombinant Langya Virus Fusion Protein (F), N-His is a recombinant protein expressed from E.coli. Its predicted molecular weight is 42.0 kDa. The purity is>90% (SDS-PAGE).
Specifications
Target Information
In veterinary medicine, the function of Langya virus fusion protein (F) is to facilitate the fusion of the virus with the host cell membrane. The F protein is a type I transmembrane protein that can be cleaved into disulfide-linked F1 and F2 subunits by enzymes such as cathepsin L, a process essential for membrane fusion. The F protein transitions from a metastable prefusion form to an extended postfusion form to promote host cell entry. Prefusion F protein elicits higher neutralizing antibody titers than postfusion F protein, suggesting that stabilization of prefusion F may aid in vaccine development. Thus, the F protein plays a key role in the infection mechanism of Langya virus and in the design of vaccines.
Shipping and Storage
This product is shipped with dry ice. Avoid repeated freezing and thawing. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Reconstitute to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.Aliquote the reconstituted solution to minimise freeze-thaw cycles.
References
- May, Aaron J, et al.et alStructures of Langya Virus Fusion Protein Ectodomain in Pre- and Postfusion Conformation. Journal of virology2023, 97(6): e0043323.