Recombinant Mouse Apolipoprotein E (Apoe), C-His

Mouse Apolipoprotein E (Apoe) is a major component of various lipoprotein particles, including chylomicrons, very-low-density lipoproteins, and high-density lipoproteins, playing a critical role in lipid transport and metabolism. Apoe serves as a ligand for LDL receptors and their relatives, facilitating the uptake of lipoprotein particles by the liver and other tissues. In mice, Apoe is synthesized primarily in the liver and brain, where it participates in the clearance of dietary lipids and the maintenance of lipid homeostasis. The Apoe gene exists in different isoforms, with Apoe4 being associated with an increased risk of Alzheimer's disease and other neurodegenerative disorders. Research on Apoe in mice has provided valuable insights into its functions in lipid metabolism, atherosclerosis development, and neurodegenerative diseases, highlighting its importance as a therapeutic target for these conditions.