Recombinant Mouse Fractalkine (CX3CL1), C-His

Mouse Fractalkine, or CX3CL1, is a chemokine involved in immune cell recruitment and activation. In mouse models, CX3CL1 is used to study its roles in inflammation and neurodegenerative diseases. CX3CL1 is unique among chemokines as it can exist both in a soluble form and as a membrane-bound molecule, allowing it to mediate both chemotactic and adhesive functions. It specifically interacts with its receptor, CX3CR1, which is expressed on immune cells such as monocytes, macrophages, and natural killer cells. In the central nervous system, CX3CL1 plays a crucial role in the interaction between neurons and microglia, modulating neuroinflammatory responses and synaptic plasticity. Research on CX3CL1 has also implicated it in the pathogenesis of various inflammatory conditions, including atherosclerosis and rheumatoid arthritis, where it contributes to the recruitment and retention of immune cells in affected tissues.