Recombinant Mouse Tumor Necrosis Factor Receptor Superfamily Member 5 (CD40), C-Fc

Mouse Tumor Necrosis Factor Receptor Superfamily Member 5, or CD40, is a tumor necrosis factor receptor involved in immune response regulation. In mouse studies, CD40 is explored for its roles in immune cell interactions and immune responses. CD40 is expressed on antigen-presenting cells such as dendritic cells and B cells, and its ligand, CD40L, is primarily found on activated T cells. The CD40-CD40L interaction is crucial for the initiation and regulation of adaptive immune responses, as it provides essential signals for the activation, differentiation, and survival of B cells and dendritic cells. In the context of cancer immunotherapy, CD40 agonists have been developed to enhance antitumor immune responses by promoting the maturation of dendritic cells and the activation of cytotoxic T cells. However, dysregulated CD40 signaling has also been implicated in various pathological conditions, including autoimmune diseases and transplant rejection, where excessive immune activation can cause tissue damage. Research on CD40 continues to uncover its complex roles in different immune-mediated processes and to identify strategies for modulating its activity in therapeutic settings.