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Recombinant Staphylococcus aureus Immunoglobulin G-binding Protein A (SPA), C-His
Product Overview
BioVenic's Recombinant Staphylococcus aureus Immunoglobulin G-binding Protein A (SPA), C-His is a recombinant protein expressed from E.coli. Its predicted molecular weight is 33.9 kDa. The purity is>90% (SDS-PAGE).
Specifications
Target Information
Staphylococcus aureus immunoglobulin G-binding protein A (SpA) is a key virulence factor that plays a significant role in immune evasion by binding to the Fc region of IgG, thereby inhibiting the host's innate and adaptive immune responses. This protein effectively cloaks the bacterial cell with IgG, blocking interactions with Fc receptors on neutrophils and hindering phagocytosis. Moreover, SpA can also act as a B-cell superantigen, inducing proliferation and depletion of the B-cell repertoire.
Shipping and Storage
This product is shipped with dry ice. Avoid repeated freezing and thawing. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Reconstitute to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.Aliquote the reconstituted solution to minimise freeze-thaw cycles.