Mouse Anti-Canine Adenylosuccinate Lyase (ADSL) Monoclonal Antibody

Canine adenylosuccinate lyase (ADSL) is an enzyme that plays a dual role in the de novo synthesis of purine nucleotides and the purine nucleotide cycle. It catalyzes the conversion of succinylaminoimidazole carboxamide ribotide (SAICAR) to aminoimidazole carboxamide ribotide (AICAR) and the formation of adenosine monophosphate (AMP) from succinyladenosine monophosphate (S-AMP). ADSL deficiency in dogs can lead to the accumulation of SAICAr and S-Ado, which are the dephosphorylated forms of the ADSL substrates SAICAR and S-AMP, respectively, and serve as biochemical markers of the disorder. This enzyme is crucial for maintaining adenosine monophosphate (AMP) levels and favoring the production of adenosine triphosphate (ATP), making it a significant target for understanding and managing metabolic disorders in dogs.