Mouse Anti-Canine Importin Beta 1 Monoclonal Antibody

Canine importin beta 1 (KPNB1) is a conserved nuclear transport receptor that plays a pivotal role in the nuclear import of proteins containing nuclear localization signals (NLS) in eukaryotic cells, including dogs. It is crucial for various cellular processes such as DNA replication, DNA repair, transcriptional control, and epigenetic regulation of gene expression. In addition to its role in interphase nuclei, Importin Beta 1 is also a global regulator of mitosis, influencing mitotic spindle organization, and function. Overexpression of Importin Beta 1 is observed in many cancer types, suggesting its potential as a therapeutic target in oncology. In dogs, understanding the function of Importin Beta 1 is essential for insights into nuclear transport mechanisms and its implications in health and disease, particularly in cancer biology.