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Mouse Anti-Canine Importin Beta 1 Monoclonal Antibody

Cat. No.VD11N45

Product TypeAnimal-targeted Antibodies

Size 100 μg

Product Overview

BioVenic mouse monoclonal antibody is specific for canine importin beta 1. It can be applied to WB, ICC/IF, FACS, IP, ChIP and IHC assays of canine importin beta 1.

Specifications

Application WB; ICC/IF; FACS; IP; ChIP; IHC
Clonality Monoclonal
Classification Primary Antibody
Clone S9N45
Host Mouse
Target Species Canine
Species Reactivity Canine
Specificity Canine Importin Beta 1
Isotype IgG2
Immunogen Recombinant protein of importin beta 1
Concentration 1 mg/mL
Conjugation Unconjugated
Preservative and Stabilizer 0.05% Sodium Azide
Buffer Phosphate Buffered Saline
Physical State Liquid

Target Information

Canine importin beta 1 (KPNB1) is a conserved nuclear transport receptor that plays a pivotal role in the nuclear import of proteins containing nuclear localization signals (NLS) in eukaryotic cells, including dogs. It is crucial for various cellular processes such as DNA replication, DNA repair, transcriptional control, and epigenetic regulation of gene expression. In addition to its role in interphase nuclei, Importin Beta 1 is also a global regulator of mitosis, influencing mitotic spindle organization, and function. Overexpression of Importin Beta 1 is observed in many cancer types, suggesting its potential as a therapeutic target in oncology. In dogs, understanding the function of Importin Beta 1 is essential for insights into nuclear transport mechanisms and its implications in health and disease, particularly in cancer biology.

Target Canine Importin Beta 1
Target Synonym Karyopherin subunit beta 1; KPNB1
Gene ID 491042
UniProt ID A0A8I3NZP6

Shipping and Storage

This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.

Documents

COA

To request a Certificate of Analysis, please enter the Lot No. in the search box. Note: Certificate of Analysis not available for kits.

The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.

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