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Mouse Anti-Canine Smoothened Homolog (SMO) Monoclonal Antibody
Product Overview
BioVenic mouse monoclonal antibody is specific for smoothened homolog. It is affinity purified by protein G. It can be applied to IF and ELISA assays of smoothened homolog.
Specifications
Target Information
Canine smoothened homolog (cSmo) is the dog ortholog of the human smoothened protein (Smo), which is a key component in the hedgehog signaling pathway. This pathway plays a critical role in the development of embryos, tissue regeneration, and the maintenance of stem cell populations. cSmo, a G-protein coupled receptor, functions as a crucial transducer of the Hedgehog signal. When the Hedgehog ligand binds to its receptor, Patched (Ptch), it relieves the inhibition of cSmo, leading to the activation of the downstream signaling cascade that regulates gene expression involved in cell differentiation, proliferation, and survival.
Shipping and Storage
This product is shipped with ice gel packs. Store at -20°C (up to 12 months) on receipt.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
References
- Jeng, Kuo-Shyang, et al. "The role of smoothened in cancer." International journal of molecular sciences 21.18 (2020): 6863.