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Mouse Anti-Porcine Glucokinase (GCK) Monoclonal Antibody
Product Overview
BioVenic mouse monoclonal antibody is specific for glucokinase. It is affinity purified by protein G. It can be applied to WB, IF, IHC and Indirect ELISA assays of glucokinase.
Specifications
Target Information
Porcine glucokinase (GCK) is a key enzyme in glucose metabolism, catalyzing the first step of glycolysis in the liver and pancreas by converting glucose to glucose-6-phosphate. This enzyme plays a crucial role in glucose homeostasis, functioning as the body's primary glucose sensor due to its unique sigmoidal kinetic response to glucose levels. In pigs, GCK is essential for maintaining whole-body glucose balance, with its activity regulated at multiple levels, including conformational dynamics, protein-protein interactions, and post-translational modifications.
Shipping and Storage
This product is shipped with ice gel packs. Store at -80°C on receipt.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
References
- Barzilai, Nir, et al. "Role of glucokinase and glucose-6-phosphatase in the acute and chronic regulation of hepatic glucose fluxes by insulin." Journal of Biological Chemistry 268.33 (1993): 25019-25025.