Mouse Anti-Canine Serine/Threonine Kinase 3 (STK3) Monoclonal Antibody

Canine serine/threonine kinase 3 (STK3) is a crucial enzyme within the Hippo tumor suppressor pathway, playing a significant role in cell development, proliferation, and apoptosis. It functions as a tumor suppressor in various cancers, including pancreatic cancer, by inhibiting cell growth and promoting apoptosis. STK3's activity is associated with the regulation of the PI3K/AKT/mTOR pathway, a key signaling mechanism involved in cell growth and survival. In canine health, STK3's influence on cellular functions extends beyond the Hippo pathway, impacting apoptosis, autophagy, and stress response. Its downregulation in pancreatic cancer has been linked to the promotion of cell proliferation and invasion, highlighting its potential as a therapeutic target for cancer treatment in dogs.