Mouse Anti-Porcine Pleckstrin Homology Domain Containing B2 (PLEKHB2) Monoclonal Antibody

Porcine pleckstrin homology domain containing B2 (PLEKHB2) is an integral part of the broader family of PH domain proteins, which are significant in cell signaling and cytoskeletal regulation. The PH domain, found in over 250 proteins in humans, is the 11th most common domain in the human proteome. This domain is known for its ability to bind phosphoinositides, which can translocate the host protein to cell membranes, promoting adjacent domain activity or inhibiting it by folding over. In pigs, the PLEKHB2 likely serves a similar function, interacting with the cell membrane and playing a role in signaling pathways. The binding of PH domains to phosphoinositides is crucial for cellular processes such as actin assembly and cell polarization. These domains are also implicated in a variety of human diseases, including cancer, hyperproliferation, neurodegeneration, inflammation, and infection. The structure of the PH domain has allowed for the development of inhibitors that can selectively bind to the domain, offering potential therapeutic approaches for diseases involving the PH domain.