Mouse Anti-Canine NCX1 Monoclonal Antibody

Canine NCX1, or sodium-calcium exchanger 1, is a crucial membrane protein that facilitates the exchange of sodium and calcium ions across the cell membrane. It plays a significant role in regulating intracellular calcium levels, which is vital for cardiac function and muscle contraction. In the heart, NCX1 is particularly important for maintaining the balance of calcium ions during the excitation-contraction coupling process. This protein is also involved in the physiological conditions of the heart, operating in either Ca2+ exit or entry mode depending on the membrane potential and ion gradients. The regulation of NCX1 is complex and involves various cytoplasmic factors, including exchanger inhibitory peptide (XIP), Na+, Ca2+, and protein kinase C (PKC).