Mouse Anti-Porcine Kinesin Family Member 5A (KIF5A) Monoclonal Antibody

Porcine kinesin family member 5A (KIF5A) is a motor protein that plays a vital role in intracellular transport, particularly in neurons where it is involved in the anterograde movement of organelles, proteins, and RNA along microtubules. KIF5A is essential for neuronal morphogenesis, function, and survival, and its dysfunction has been implicated in several neurodegenerative disorders such as hereditary spastic paraplegia (HSP10), Charcot-Marie-Tooth disease type 2 (CMT2), and Amyotrophic Lateral Sclerosis (ALS). Recent studies have shown that KIF5A mediates lysosomal functions, which are crucial for the cell's ability to degrade and recycle components. In the context of neurotoxicity, KIF5A's expression is significantly reduced upon cadmium exposure, leading to impaired lysosomal function and inhibition of neuronal cell viability and protrusion growth, highlighting its potential as a target for neuroprotective interventions. Additionally, computational studies have identified key regulatory mechanisms and potential therapeutic targets for KIF5A, such as the nsSNPs and bioactive compounds like epigallocatechin gallate, which could have implications for ALS and other neurodegenerative diseases.