Mouse Anti-Porcine NADP-Dependent Malic Enzyme (ME1) Monoclonal Antibody

Porcine NADP-dependent malic enzyme (ME1) is a vital oxidative decarboxylase that catalyzes the conversion of L-malate to pyruvate, simultaneously reducing NADP+ to NADPH. This enzyme is essential for energy metabolism, playing a significant role in the tricarboxylic acid (TCA) cycle and providing reducing power for biosynthetic pathways. In pigs, ME1 is implicated in various physiological functions, including the maintenance of cytoplasmic pH, regulation of stomatal aperture, and enhancement of resistance to environmental stresses such as aluminum toxicity and pathogen attacks. The enzyme also contributes to the synthesis of defense compounds like flavonoids and lignin, which are crucial for tolerance against mechanical wounding and pathogen invasion. Moreover, ME1 is a key source of NADPH, which is vital for antioxidant defense systems, including the ascorbate-glutathione pathway and NADPH-dependent thioredoxin reductase.