Mouse Anti-Porcine Phosphodiesterase 6D (PDE6D) Monoclonal Antibody

Porcine phosphodiesterase 6D (PDE6D) is an enzyme that plays a significant role in the phototransduction cascade within rod cells of the retina. This enzyme is specifically involved in the hydrolysis of cGMP, which is a key step in the process of visual signal transduction. The PDE6D gene encodes the delta subunit of the rod-specific photoreceptor phosphodiesterase (PDE), and its function is crucial for maintaining the sensitivity of the rod cells to light. In pigs, PDE6D may have a role similar to that in humans, where it is associated with visual processes. Mutations in the PDE6D gene have been linked to Joubert syndrome-22, a disorder that affects the development of the brain, particularly the cerebellum, and can lead to visual impairments. This suggests that PDE6D is not only important for normal vision but also for the development and function of the brain.