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Recombinant Bovine Sulfite Oxidase (SUOX), N-His
Product Overview
BioVenic's Recombinant Bovine Sulfite Oxidase (SUOX), N-His is a recombinant protein expressed from E.coli. Its predicted molecular weight is 29.0 kDa. The purity is>97% (SDS-PAGE).
Specifications
Target Information
Bovine sulfite oxidase (SUOX) is an enzyme that plays a critical role in the metabolism of sulfur-containing amino acids, specifically in the final step of converting sulfite to sulfate. This process is essential for detoxifying sulfites and is involved in maintaining cellular homeostasis. SUOX is localized to the mitochondrial membrane and consists of two identical subunits, each with redox centers. Deficiency in this enzyme can lead to severe neurological abnormalities and early death in humans, known as sulfocysteinuria. In cattle, mutations in the SUOX gene have been linked to arachnomelia, a condition characterized by severe skeletal defects and neonatal lethality.
Shipping and Storage
This product is shipped with dry ice. It is recommended to aliquot as needed and store at -80°C upon receipt. Reconstituted protein solution can be stored at 4°C for 1 week, at < -80°C for 12 months. Avoid repeated freezing and thawing.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Reconstitute in 10mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Aliquot the reconstituted solution to minimise freeze-thaw cycles.
References
- Drögemüller, Cord. et al.Identification of the Sheep Arachnomelia mutation by massively parallel sequencing implicates sulfite oxidase (SUOX) in bone development.PLoS genetics. 2010, 6,8 e1001079: 26