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Recombinant Canine CD40 ligand (CD40LG)
Product Overview
BioVenic's Recombinant Canine CD40 ligand (CD40LG) is a recombinant protein expressed from HEK293 Cell. Its predicted molecular weight is 16.0 kDa. The purity is>95% (SDS-PAGE).
Specifications
Target Information
Canine CD40 Ligand (CD40LG) is a member of the TNF superfamily, transiently expressed on activated T cells. It binds to CD40 on antigen-presenting cells (APCs), promoting their activation and maturation. In dogs, CD40LG is crucial for B cell function and immune responses, including immunoglobulin class switching and germinal center formation. It also enhances dendritic cell maturation and activation, which is vital for antigen presentation and T cell activation. Additionally, CD40LG has therapeutic potential in cancer immunotherapy, as shown in studies where it was used to treat canine melanoma, resulting in immune cell infiltration and tumor regression.
Shipping and Storage
This product is shipped with ice packs. Lyophilized protein can be stored at -20°C for 1 year. After reconstitution, the protein solution can be stored at 2-8°C for 2-7 days.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Aliquot the reconstituted solution to minimize freeze-thaw cycles.