Recombinant Mouse P-selectin Glycoprotein Ligand 1 (Selplg), C-Fc

Mouse P-selectin Glycoprotein Ligand 1 (Selplg), also known as CD162, is a glycoprotein expressed on the surface of leukocytes and platelets that mediates cell adhesion and rolling during inflammation and hemostasis. Selplg interacts with P-selectin on endothelial cells and platelets, facilitating leukocyte tethering and rolling at sites of vascular injury or inflammation. In mice, Selplg plays a crucial role in the recruitment of leukocytes to sites of infection and tissue damage, contributing to the initiation and propagation of immune responses. Research on Selplg in mice has provided insights into its functions in leukocyte trafficking, inflammation, and thrombosis, highlighting its importance as a therapeutic target for inflammatory and thrombotic diseases.