Recombinant Mouse Tumor Necrosis Factor Receptor Superfamily Member 21 (Tnfrsf21), C-Fc-His

Mouse Tumor Necrosis Factor Receptor Superfamily Member 21 (Tnfrsf21), also known as Death Receptor 6 (DR6), is a member of the TNF receptor superfamily. It is widely expressed in tissues such as lymphoid organs, heart, brain, and pancreas. Tnfrsf21 can trigger apoptosis and activate signaling pathways like JNK and NF-κB upon ligand binding. In the immune system, Tnfrsf21 regulates T and B cell functions, influencing their proliferation, activation, and cytokine production. Research indicates that Tnfrsf21-deficient mice exhibit enhanced immune responses and resistance to certain autoimmune diseases. Additionally, Tnfrsf21 is overexpressed in various tumor cells, suggesting its potential role in cancer biology. Understanding the complex roles of Tnfrsf21 in immune regulation and disease pathogenesis could open avenues for developing targeted therapies.