Recombinant Mycobacterium tuberculosis 6 kDa Early Secretory Antigenic Target (esxA), C-His

Mycobacterium tuberculosis 6 kDa early secretory antigenic Target , also known as esat6, is a key virulence factor in the pathogenesis of tuberculosis. In veterinary medicine, ESAT-6 plays a significant role in understanding and combating. Mycobacterium bovis, the causative agent of bovine tuberculosis, which is closely related to M. tuberculosis. This protein is crucial for the survival of the bacteria within macrophages and its spread to other cells. It is involved in the inhibition of autophagy, triggering of necrosis, and the stimulation of cytokine production, which creates a chronic proinflammatory environment at the site of infection. Additionally, ESAT-6 is a major target for diagnostic tests and vaccine development due to its immunodominant nature . Understanding the role of ESAT-6 in disease progression can guide therapeutic interventions and help in the development of more effective vaccines for animals, thereby controlling the spread of tuberculosis in veterinary populations.