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Biotinylated Recombinant Equine Frizzled Class Receptor 8 (FZD8), C-6His-Avi
Product Overview
BioVenic's Biotinylated Recombinant Equine Frizzled Class Receptor 8 (FZD8), C-6His-Avi is a recombinant protein expressed from Mammalian expression system. Its predicted molecular weight is 19 kDa. The purity is greater than 95% (SDS-PAGE). The endotoxin level is <1 EU/μg (LAL). It has a C-terminal 6His Avi tag.
Specifications
Target Information
Frizzled-8 (FZD8) is one of at least ten seven-transmembrane (7TM) glycoproteins of the Frizzled family of Wnt receptors. Frizzled proteins are thought to be G-protein coupled. Research has shown that FZD8 forms a TGF-β regulated complex with TGF-β receptors mediated by the extracellular domains of FZD8 and TGFBR1.
Shipping and Storage
This product is shipped with dry ice. It is recommended to aliquote as needed and store at -20°C upon receipt. Reconstituted protein solution can be stored at 4°C for 1 week, at < -20°C for 3 months.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Dissolve the lyophilized protein in distilled water. Avoid mixing by vortexing or pipetting. It is not recommended to reconstitute to a concentration < 100 μg/mL. Aliquote the reconstituted solution to minimise freeze-thaw cycles.
References
- Murillo-Garzón, V. et al. Frizzled-8 integrates Wnt-11 and transforming growth factor-β signaling in prostate cancer. Nature communications. 2018, 9: 1747.