Mouse Anti-Canine ATP5B Monoclonal Antibody

Canine ATP5B, also known as the β-subunit of mitochondrial ATP synthase, is a crucial component of the enzyme responsible for ATP production within the mitochondria of cells. This protein plays a pivotal role in cellular energy metabolism by facilitating the phosphorylation of adenosine diphosphate (ADP) to ATP, using the proton gradient across the mitochondrial membrane. ATP5B is part of the F1 domain of the ATP synthase complex, which is located in the mitochondrial matrix and exhibits catalytic activity. Recent studies have also indicated that ATP5B may have extra-mitochondrial roles, including its presence on the plasma membrane where it can influence cellular processes such as cholesterol homeostasis. Understanding the function of canine ATP5B is essential for insights into energy metabolism and its potential implications in health and disease, particularly in conditions related to mitochondrial dysfunction or energy metabolism disorders.