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Mouse Anti-Canine Dihydrofolate Reductase (DHFR) Monoclonal Antibody

Cat. No.VD11N52

Product TypeAnimal-targeted Antibodies

Size 100 μL

Product Overview

BioVenic mouse monoclonal antibody is specific for canine dihydrofolate reductase. It can be applied to WB and IHC assays of canine dihydrofolate reductase.

Specifications

Application WB; IHC
Clonality Monoclonal
Classification Primary Antibody
Clone S13N4
Host Mouse
Target Species Canine
Species Reactivity Canine
Specificity Canine Dihydrofolate Reductase
Isotype IgG2
Immunogen Recombinant protein of dihydrofolate reductase
Concentration 1.2 mg/mL
Conjugation Unconjugated
Preservative and Stabilizer 0.02% Sodium Azide
Buffer Phosphate Buffered Saline, 1% BSA, 50% Glycerol
Physical State Liquid

Target Information

Canine dihydrofolate reductase (DHFR) is a ubiquitous enzyme that plays a critical role in the biosynthesis of tetrahydrofolate cofactors, essential for the transfer of C1 carbon moieties in various biosynthetic pathways, including the synthesis of purines, amino acids like glycine and methionine, and thymidine. This enzyme was discovered as the target for antifolate drugs such as methotrexate in mammalian systems, and also for antibacterial agents like trimethoprim and antiprotozoal agents like pyrimethamine. DHFR's key function in folate metabolism makes it a significant target for drugs used in cancer treatment, antibacterial therapy, and other antiparasitic medications.

Target Canine Dihydrofolate Reductase
Target Synonym DHFR
Gene ID 479165
UniProt ID A0A8C0NPY6

Shipping and Storage

This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.

Documents

COA

To request a Certificate of Analysis, please enter the Lot No. in the search box. Note: Certificate of Analysis not available for kits.

The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.

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