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Mouse Anti-Canine Lem Domain Containing 3 (LEMD3) Monoclonal Antibody

Cat. No.VD11N171

Product TypeAnimal-targeted Antibodies

Size 100 μL

Product Overview

BioVenic mouse monoclonal antibody is specific for canine lem domain containing 3. It can be applied to WB and IP assays of canine lem domain containing 3.

Specifications

Application WB; IP
Clonality Monoclonal
Classification Primary Antibody
Clone S15N11
Host Mouse
Target Species Canine
Species Reactivity Canine
Specificity Canine Lem Domain Containing 3
Isotype IgG1
Immunogen Recombinant protein of lem domain containing 3
Concentration 0.61 mg/mL
Conjugation Unconjugated
Preservative and Stabilizer 0.02% Sodium Azide
Buffer Phosphate Buffered Saline, 1% BSA, 50% Glycerol
Physical State Liquid

Target Information

Canine lem domain containing 3 (LEMD3) is an integral inner nuclear membrane protein that antagonizes TGFβ-SMAD2/3 signaling in a stiffness-dependent manner, both in the nucleus and cytosol. It plays a role in the regulation of extracellular matrix (ECM) stiffness and TGFβ activation, which are key drivers of pathological fibrosis in multiple organ systems. LEMD3 binds and inactivates the downstream transcription factor partners of TGFβ and BMP, the receptor proteins' mothers against decapentaplegic (Smads) 2 and 3. This protein's interaction with Smads and its role in mechanotransduction make it a significant target for understanding and potentially treating fibrosis and other ECM-related pathologies in dogs.

Target Canine Lem Domain Containing 3
Target Synonym LEMD3
Gene ID 608380
UniProt ID A0A8P0NPA0

Shipping and Storage

This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.

Documents

COA

To request a Certificate of Analysis, please enter the Lot No. in the search box. Note: Certificate of Analysis not available for kits.

The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.

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