Mouse Anti-Porcine Cartilage Oligomeric Matrix Protein (COMP) Monoclonal Antibody

Porcine cartilage oligomeric matrix protein (COMP), also known as thrombospondin-5, is a large, multi-domain extracellular matrix protein that is abundant in cartilage and other connective tissues. COMP plays a crucial role in the structural integrity of cartilage, contributing to its resistance to compression and tensile forces. It interacts with various components of the extracellular matrix, including collagen and proteoglycans, and is involved in the regulation of chondrocyte function. As a molecular target, COMP is significant due to its association with cartilage homeostasis and its potential role in the pathogenesis of osteoarthritis and other joint diseases. Changes in COMP expression or structure have been observed in conditions characterized by cartilage degradation, making it a potential biomarker and therapeutic target for these diseases.