Mouse Anti-Porcine CD45 Monoclonal Antibody

Porcine CD45, known as the "leukocyte common antigen," is a protein tyrosine phosphatase that is widely expressed on the surface of all nucleated hematopoietic cells in pigs, including T cells, B cells, and macrophages. It is a key regulator of immune cell signaling pathways, playing a critical role in the activation, proliferation, and function of these cells. CD45 acts by dephosphorylating specific tyrosine residues on target proteins, thereby modulating signal transduction. This activity is essential for the proper functioning of the immune system, as it helps to fine-tune the response to antigens and maintain immune homeostasis. Disruptions in CD45 function can lead to various immunodeficiencies and autoimmune diseases. Targeting CD45 in pigs can provide insights into the mechanisms of immune regulation and may offer therapeutic approaches for managing immune-related conditions in veterinary medicine.